According to a study, patients with extended COVID-19 syndrome continue to have increased blood clotting levels, which might explain their ongoing symptoms including decreased physical fitness and tiredness.
Long COVID-19 syndrome, which includes dyspnea, tiredness, and reduced exercise tolerance, can continue weeks to months after the original infection has cleared up, and millions of people are thought to be affected globally.
Researchers from Ireland’s RCSI University of Medicine and Health Sciences studied 50 individuals with extended COVID-19 syndrome symptoms to see if irregular blood coagulation is involved.
Their research, which was published in the Journal of Thrombosis and Haemostasis, discovered that clotting indicators in the blood of individuals with extended COVID syndrome were substantially higher than in healthy controls.
These coagulation indicators were greater in individuals who had to be admitted to the hospital because of their COVID-19 infection.
However, even individuals who were able to manage their sickness at home had chronically elevated clotting indicators, according to the researchers.
They discovered that increased clotting was linked to other symptoms of extended COVID-19 syndrome, such as tiredness and decreased physical fitness.
Even when all inflammatory indicators were returned to baseline, long COVID-19 patients still showed an elevated clotting propensity.
“Our findings suggest that the clotting system may be involved in the root cause of long COVID syndrome because clotting markers were elevated while inflammation markers returned to normal,” said Helen Fogarty, the study’s lead author and PhD student at RCSI School of Pharmacy and Biomolecular Sciences.
Understanding the core cause of an illness, according to Professor James O’Donnell, Director of the Irish Centre for Vascular Biology at RCSI, is the first step toward finding successful therapies.
“Millions of individuals are currently coping with the symptoms of long COVID syndrome, and as infections among the unvaccinated continue to occur, more people will acquire long COVID,” O’Donnell warned.
“It is critical that we continue to research and develop viable therapies for this illness,” he added.
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